Scientific journal
Scientific Review. Technical science
ISSN 2500-0799
ПИ №ФС77-57440

Personal portfolio

STRUCTURE OF POROUS COMPOSITE MATERIALS BASED ON POLYHYDROXYBUTYRATE FOR TISSUE ENGINEERING

Senatov F.S. 1 Cherdyntsev V.V. 1 Senatova S.I. 1
1 National University of Science and Technology “MISIS”
Porous composite materials based on biodegradable polyhydroxybutyrate (PHB) and hydroxyapatite (HAP), filled with anti-microbial agent, colloidal silver, were obtained by mechanical mixing and hot-pressing. The obtained samples of the materials were studied by scanning electron microscopy and FTIR spectroscopy. The analysis of the obtained composite products after implantation into the body of laboratory mice for 30 days shows the change in the structure of PHB matrix associated with biodegradation. The method of obtaining a composite leads to a uniform distribution of filler and allows to obtain porous bulk samples with high pore volume fraction of more than 30%, a wide distribution of pore size from 10 microns to 500 microns distributed along the walls and surfaces of the bioactive filler. In this case, the pores are open and conjugate with each other with network of channels and cavities. It is demonstrated that impregnation of a porous compacted PHB / GAP with colloidal silver solution results in a uniform distribution of it over the surface of the sample and the walls of the open pores without significantly changing of dispersion.